I-79 north to I-70 (little Washington)
I-70 west to I-74 (Indianapolis)
I-74 west to I-80 (Davenport/Moline)
I-80 till we see lots of salt
2,035 miles

Assuming that we make it to Columbus on Wednesday (200 miles)...

Moderate pace:
Thursday depart Columbus, arrive Des Moines (646 mi, est. 11 hrs)
Friday depart Des Moines, arrive Laramie (681 mi, est. 11.5 hrs)
Saturday depart Laramie, arrive Wendover (503 mi, est. 8.5 hrs)

Hoofin' it:
Thursday depart Columbus, arrive Omaha (781 mi, est. 13 hrs)
Friday depart Omaha, arrive Rock Springs WY (754 mi, est. 12.5 hrs)
Saturday depart Rock Springs, arrive Wendover (295 mi, est. 5 hrs)

MD, WV, PA, OH, IN, IL, IA, NE, WY, UT, and NV